Tuesday, December 31, 2019
Dreams And Visions Is Jesus Awakening The Muslim World
For six years, Ibrahim had been unconvincingly told by Muslim religious leaders in his city that the appearance of a glorious man in his dream was surely the Prophet Muhammad. When Ibrahim decided to share his dream with a Christian missionary in his town, he was overjoyed to find that the man who had come to him in his dream was not the Prophet Muhammad, but the same man found and described in Revelation 1:12-16. Before the encounter with the Christian missionary, Ibrahim had never heard of, much less read from the Bible. The discussion of his dream with the missionary ultimately led to a proclamation of the Gospel, in which Ibrahim would hear the Gospel for the first time, and ultimately come to faith in it weeks later. Stories ofâ⬠¦show more contentâ⬠¦Instead, it is important that the subject is approached with a sense of openness for the skeptic and a healthy amount of caution for the readily believing. In an over-arching sense, the subject must be approached carefully and critically. Before moving further in the discussion of the continuation of dreams and visions as a means of Godââ¬â¢s continued revelation today, it would be important to define briefly what exactly dreams and visions are. Defining Dreams and Visions It may seem unnecessary to define something as common to us as dreams. Each and every person, in one degree of lucidity or another, has experienced dreams and does so on a recurring basis. In defining and understanding what exactly dreams and visions are, along with their similarities and differences, we continue to turn to Morton T. Kelsey. Kelsey notes that, while we cannot certainly understand what sleep is, we can understand that it is a specific type of consciousness, a transient interruption of the waking state. During this interruption of the waking state, there are two states that appear to take effect in the human brain, known by psychologists as the ââ¬Å"primary-process activityâ⬠and the ââ¬Å"secondary-process mentation.â⬠The primary-process activity is the time during sleep in which the sleeper experiences a single picture or figure, or even a vivid and elaborate story. It is not uncommon for the sleeper to experience this phase ofShow MoreRelatedThe Functi on Of Prayer And The Islamic Faith1430 Words à |à 6 Pagesmonotheistic faith which centers around the sovereignty of Allah, the five pillars of faith, and the sanctity of the Qurââ¬â¢an. à Christianity views Islamic prayer as an opportunity for the real God reveal the truth to Muslims. à à à à à ââ¬Å"Islam is the fastest-growing major religion in the worldâ⬠(Taylor). à In Islam, Allah is almighty (Qurââ¬â¢an Sura 67:2). à The five pillars of faith, Shahada, Salat, Zakat, Hajj and Sawm, are a constant reminder of a Muslimââ¬â¢s devotion to Allah. à The five pillars are essentialRead MoreSwami Vivekananda14669 Words à |à 59 Pageshere, only in a more clear sense. Narendra was astounded and puzzled. He could feel the mans words were honest and uttered from depths of experience. He started visiting Ramakrishna frequently. Though Narendra could not accept Ramakrishna and his visions, he could not neglect him. It had always been in Narendras nature to test something thoroughly before he could accept it. He tested Ramakrishna to the maximum, but the master was patient, forgiving, humorous and full of love. He never asked NarendraRead MoreProject Managment Case Studies214937 Words à |à 860 Pagesyears, primarily due to the advanced technology developed by their Eton Division, which produces disk drives. Continental is considered one of the giants in computer technology development, and supplies equipment to other computer manufacturers. World headquarters for CCC is in Concord, Illinois, a large suburb northwest of Chicago in the heart of Illinois s technology center. In addition to corporate headquarters, there are three other divisions: the Eton Division, which manufactures disk drives
Monday, December 23, 2019
Technical And Business Of Entrepreneurship - 869 Words
â⬠¢ Technical and Business Undergraduatesââ¬Å¸ Self-Efficacy in Entrepreneurship This paper investigated how particular and business student see their ability to adjust, perform and be viable in big business. Past investigation revelations suggest that entrepreneurial objectives and exercises are impacted by individuals self-respect or self-efficacy identifying with the confidence and saw competency in business issues. Seen wellness much of the time implies data, capacities and conduct, which are considered as the priority of confidence. In that limit, business understudies may be acknowledged to have higher self-respect in business endeavors than non-business students. Nineteen (31%) of the business student and 15 (29%) of the particular student had either a relative or a relative who was a specialist. Fifty-two (84%) of the business students whilst 40 (78%) of the particular student have had the mean to get required in business with most of them wanted to do all things considered inside 5 years after Bachelorââ¬â¢s degree. The stark qualification between both social events of individuals was around 17 (27%) of the business understudies diverged from only 4 (8%) of the specific student had the mean to meander into business practices rapidly after graduation. Preliminary examinations were performed to ensure no encroachment of assumptions of normality, linearity, and homoscedasticity. â⬠¢ Self-efficacy, self-esteem, and entrepreneurship among the unemployed This study focuses onShow MoreRelatedBusiness Skills As Entrepreneurship Education1203 Words à |à 5 Pageshave explained business skills as entrepreneurship education to empower knowledge of the entrepreneurs. This entails business management skills, business planning, financial management, awareness of legal aspects and market searching. That being the case, the skills are useful and important in developing creative thinking, negotiations, leadership (business management), exposure to technical innovation and new product development. However, the skills help to identify and exploit business opportunitiesRead MoreInternational Entrepreneurship at Infusion1134 Words à |à 5 PagesInternal Entrepreneurship at Infusion Grand Canyon University LDR 640: Leadership and Innovation Michael L Verne February 29, 2012 Page 2 International Entrepreneurship at Infusion We will be examining the growth and development of Infusion, a company that has grown in the last 10 years to become a $50 million a year international software services business with over 350 employees. The vision of Infusion states ââ¬Å"Achieve global growth by measurablyRead MoreDifferent Types of Entrepreneurship1001 Words à |à 4 PagesIntroduction Entrepreneurship can simply be defined as the art and process that ââ¬Å" involves capturing ideas, converting them into products and, or services and then building a venture to take the product to marketâ⬠(Zhao, pp. 26). The essential aims to be accomplished by these procedures is the creation of a new organizations or reganerating any part of any organizations for the purpose of achieving further improvement and betterment of the comprehensive business or company. For entrepreneurs sansRead MoreSelf Efficacy Among Students From A University Or School1608 Words à |à 7 PagesThe aim of this research was to identify the level of entrepreneurial self-efficacy among students from a university or school which adopted entrepreneurial education also how entrepreneurial self-efficacy is related to gender. Self-efficacy in entrepreneurship must be measure by quantitative method. Research have come a long progress to identifying individual characteristics and skills for predicting e ntrepreneurial performance and achievement. Introduction A person belief their ability to successfulRead MoreCan Entrepreneurship Be Taught1355 Words à |à 6 Pagesâ⬠¢ Can we teach entrepreneurship and bring some entrepreneurial awareness and changes among individuals. Give evidence Approach in answering the Question â⬠¢ Definition of Entrepreneurship â⬠¢ Entrepreneurship education â⬠¢ Approaches to teach entrepreneurship â⬠¢ Conclusion The concept of entrepreneurship There is no universal agreed definition of entrepreneurship. However, Entrepreneurship is defined differently by different scholars. Schumpeter (1934) defines Entrepreneurship as a personââ¬â¢s abilityRead MoreThe Academy Of Business And Entrepreneurship Charter School1408 Words à |à 6 PagesI. SCHOOL DESIGN The Academy of Business and Entrepreneurship Charter School is a K-12 model school utilizing a unique combination of PA Common Core Standards aligned curriculum and specialized programming with a focus on developing 21st Century skills to prepare students for their post- secondary goals. It will open its doors in 2014, starting with 240 students in grades K-5 and add a grade a year to reach K-9 during the course of the initial charter. However, as the model is envisioned as a fullRead MoreEntrepreneurship Education Of Chemical Engineering1591 Words à |à 7 PagesEntrepreneurship Education in Chemical Engineering Economic trends and rapidly changing hiring conventions are fueling a rapid expansion in value awareness of entrepreneurship education to engineering students. Each year, a growing proportion of the two hundred thousand engineering graduates find work in small businesses or start-up ventures, eliciting a new type of engineer, an entrepreneurial engineer, who needs a broad range of skills and knowledge above and beyond a strong science and engineeringRead MoreThe Promise of Entrepreneurship as a Field of Research638 Words à |à 3 PagesPROMISE OF ENTREPRENEURSHIP AS A FIELD OF RESEARCH 1.0 Introduction To date, the phenomenon of entrepreneurship has lacked a conceptual framework. A research has been conducted in the difference social science disciplines and applied fields of business to create a conceptual framework for entrepreneurship. 2.0 Definition of Entrepreneurship Entrepreneurship is defined solely by the researchers in terms of who the entrepreneur is and what he or she does. The study of entrepreneurship must involveRead MoreRelationship Between Entrepreneurship And The Economic Development Essay1091 Words à |à 5 PagesBUSINESS RESEARCH METHODS Introduction This research seeks to establish the relationship between entrepreneurship and the economic development in Saudi Arabia. Entrepreneurship is the process of managing, organizing and developing a business venture in a competitive environment that is dynamic (Kuratko 2016 pp3). An entrepreneur is an inventor, leader, innovator, and pioneer and most significantly, a performer. The heart of a national advantage is often pegged on entrepreneurship. The operationRead MoreEntrepreneurship Risk, Rewards, And Reality1456 Words à |à 6 Pagesgone because of entrepreneurship. In the article ââ¬Å"Entrepreneurship Risk, Rewards, and Realityâ⬠by Timothy W. Scales, the author goes over key points about small business like development, growth, and secession. Scales focus on experiences that relate to an accomplished and an unaccomplished entrepreneur. Scales say that if an idea can become entrepreneurial, it can be big or small. Entrepreneurship is the key to innovation and growth. Since t he 1970s, scholars knew that entrepreneurship was the source
Sunday, December 15, 2019
Gay and Lesbian Advertising Free Essays
string(36) " belonging is to the gay community\." Advertising ââ¬Å"Outâ⬠of the Box In 1994, Ikea created a wave of controversy when they became one of the first companies to market to the gay community on mainstream daytime television. Despite the initial backlash; this ad eventually sparked countless other companies jump on the ââ¬Å"Gay and Lesbian Advertising Bandwagonâ⬠. But what is the motive behind advertising specifically to this community, do the businesses take a genuine interest in the gay community or is it strictly for expanding business? Additionally, once a business decides to advertise using gay content, what is the appropriate way to go about doing so, and how does their strategy differ between gays and lesbians? Only 4 to 10% of the population identifies themselves as gay or lesbian. We will write a custom essay sample on Gay and Lesbian Advertising or any similar topic only for you Order Now (Okenfull, 50) So why are businesses so concerned with gaining the support of this demographic? One of the biggest reasons being their buying power. While they donââ¬â¢t make more than heterosexual couples, a large majority are not raising children, so they have more disposable income. Thus, they have even been referred to as the ââ¬Å"Dream Marketâ⬠with a potential buying power of $641 billion annually (Okenfull, 49). Because this is the foremost reason why advertisers go after the gay community, this makes us question whether they have a genuine interest in the gay community. ââ¬Å"We market to gays and lesbians for business reasons because we want to sell out product to consumers. It doesnââ¬â¢t get more complicated than that. ââ¬Å" -Miller beer spokeswoman (Sender, 2) It is common knowledge that the only point of advertisement is to drive in more business. However, analyzing the overall impact of advertising on society, it seems as if there is more that comes into play than just a business decision. In fact, regardless of the companyââ¬â¢s motive to produce advertisements that have gay content, the overall impact of infiltrating gay content into mainstream media has actually helped advance and liberate the gay community. Big corporations not only reflect societyââ¬â¢s current values, but they are also largely responsible for shaping societyââ¬â¢s values. If there are more gay and lesbian imagery in the media, society will adapt he perception that they are everywhere and normalizes gayness. Also, having large corporations back a minority-based cause, will make the majority more accepting and make the people in opposition to the cause seem more ignorant. Essentially, even just the facade of a company publicly declaring their support for gayness makes a powerful statement to society. Not only is appearing to be in support of gay rights is something that will boost your business, but to have any anti-gay statement or claims can detrimentally hurt your company as well. In 1977, Coors was accused of firing gays, along with several other minority groups. Journal of Community Research) Not long after much controversy, chairman Pete Coors adopted an Gay-Friendly policy and also extended benefits to same-sex couples. In 2000, Coors hiked up their spending on gay advertising, putting them in the number two spot for most money spent on gay advertisements. (Chura, 1) After a company becomes seen as anti-gay, it is evident that they must fight desperately to overcome this stigma just to stay in the game. Beer is a prime example of a product thatââ¬â¢s advertisements have saturated the gay market to the extent of which if you do not participate, then youââ¬â¢re stance on gay rights is questioned. There is a very positive outcome for the many companies that show their support to the gay community as well as a negative outcome for companies that donââ¬â¢t. Despite this; it still leaves many consumers skeptical of their motives. Many advertisements, in a failed attempt to show acceptance, have become the target of gay critics. The harshest of backlash of these ads are in ones in which they depict obvious and offensive gay stereotypes. It is evident that advertisers must handle these types of ads with care, depicting gay stereotypes can lead to further segregation rather than promoting equality. Gay consumers are very skeptical to how a company presents gay advertisements, but perhaps the biggest obstacle is to still keep heterosexual consumers that are turned off by or blatantly opposed to homosexuality. When Ikea first ran their ad on daytime television, there was a positive response from gay consumers. However, during this time period it still created enough controversy that outweighed the benefits of appealing to that market. This is when agencies quickly realized that limiting their advertisements to the confines of strictly gay and lesbian print media such as OUT magazine was a safer route for the time being. Although the initial reaction by heterosexuals to this first commercial was negative and controversial, this was also a time in history where the attitude around gay media was at a turning point . Gay shows became less of a niche market, and more mainstream. ââ¬Å"More recently, gay-oriented shows such as the L Word, Will and Grace, Ellen, Queer as Folk, and Queer Eye for a Straight Guy have increasingly pushed the boundaries of cultural accepatnce of homosexuality and have diminished the risk of backlash for firms who are percieved to be ââ¬Å"gay friendly. â⬠(Okenfull, 50) Shows dealing with this content presumably have made the hetereosexual community more understanding to this type of lifestyle and generationally speaking, the current generation became much more likely to support the gay rights movement. Thus, integrating gay ads into mainstream television and print media was back on the table. Because the decision for advertisers to target the gay community is still a very controversial subject for both straight and gay consumers, it is imperative to acknowledge the vast differences in how to effectively target this audience. First, it is important to recognize gay male consumers and lesbian female consumers as a very different audience. Additionally, it is important to assess how strong their gender identity is. The strength of oneââ¬â¢s gender identity is based on several different factors, such as how strong their involvement and sense of belonging is to the gay community. You read "Gay and Lesbian Advertising" in category "Essay examples" Gay males that are identified as having a high degree of sexual identity, are more attracted to ads that display explicit gay content. (Okenfull, 54) To illustrate an ad that is ââ¬Å"explicitlyâ⬠gay, (refer to picture 1), I chose Virgin Mobiles ââ¬Å"Hook up Fearlesslyâ⬠. The ad almost positively insinuates that the two males depicted in the ad are gay, if not gay, then extremely turned on by the a gay act. This type of explicitness would be most attractive to males who have a high gay identity rather than low. There is a large power construct in this advertisement. The male with wings is forcefully holding down the other male to kiss him while the male on bottom, while he does seem submissive, he is still enjoying the act taking place. I personally like this ad; mostly because of the actual relevance to the buying process. Consumers always have an apprehension to buying products, let alone a phone contract. This ad is conveying to the potential consumer to just give in and try it. While the male on bottom might have been apprehensive about the kiss, just as ââ¬Å"Youââ¬â¢ll Love Usâ⬠guarantee gives you the freedom to chose without ââ¬Å"strings attachedâ⬠. It is a ââ¬Å"Just try it! â⬠ad, and while hooking up in an office space is taboo; doing it with with a gay angel is even more controversial and daring, and you might just ââ¬Å"Love Itâ⬠. I like this ad because it communicates the point fluidly, and replaces any uncertainty with a sense of empowerment and fearlessness. While ads like these are very effective in communicating with the demographic who have a strong sense of gender identity, low identity gays and lesbians are more responsive to a less explicit type of advertising. Generally, gays and lesbians who have a low sense of gender identity want to define themselves by traits other than just their sexual preference. By being less explicit, they get the opportunity to read between the lines, not feel alienated by their gender identity, and not have their identity to be oversexualized. To target this audience, advertisers indicates gayness without actually using a lesbian or gay couple. Instead they use implicit gay imagery which uses symbols and phrases that indicates gayness such as rainbows, pride, and being ââ¬Å"outâ⬠. (Okenfull, 55) To illustrate an add that does this, I chose Chevyââ¬â¢s electric car ad (refer to ad 2). There are a mother and father car facing their child car. The caption says ââ¬Å"Mom, Dad, Iââ¬â¢m electric. â⬠The bottom of the page uses a thin bar that is intended to look like a rainbow. The copy at the bottom is ââ¬Å"So, whatever revs your engine, we support you 100%, Happy Motor City Pride from the entire Chevrolet family. â⬠This is another ad that I think is done beautifully. They used a social norm of what society knows as the ââ¬Å"coming out sceneâ⬠. The electric car is declaring that it is not just any old car, just as a gay or lesbian would have to come out to their parents that they are not just another heterosexual. What also intrigues me about that ad is the italics on ââ¬Å"Iââ¬â¢m electricâ⬠. This is presumably a play off the upbeat ââ¬Å"Itââ¬â¢s electricâ⬠song. The car is excited to tell its parents that he is gay, conveying a sense of empowerment and excitement, instead of how we typically think of this moment, which can often be a shameful and intimidating moment for many children. I also really like the ad for itââ¬â¢s relevance to the gay community. According to a recent survey, only ? of hetereosexuals admitted to being concerned about the environment while 55% of gays and lesbians identified that they are more likely to ââ¬Å"go greenâ⬠. (Koretzky). It is targeting consumers that are interested in their message, while also encouraging acceptance and becoming empowered. While even high identity lesbians are most attracted to implicit gay imagery, their liking towards explicit lesbian imagery comes secondary (before explicit gay imagery). But interestingly enough, lesbian imagery is extremely underrepresented. It was reported that in one of leading gay and lesbian magazines, The Advocate, lesbian-targeted imagery accounted for only 3% of the magazine advertising. Why is this? (Okenfull, 65) Not only do lesbians have typically just as much buying power as gay males, but heterosexual consumers are even more comfortable with lesbian imagery over gay imagery, which lowers the risk of heterosexuals being offended or turned off from a product. In general, lesbians are less discriminated than gays. his is something that shows up in the workplace; according to a recent study, gay males make 23% less than straight males, lesbians make about the same as straight women. (Williams Institute) Perhaps society taking a particular favoritism to lesbianism is the very reason that advertisements that depicting lesbians couples in ads targeted towards lesbians are more underrepresented. There is a oversexualization attenuated by the het erosexual community of how lesbians are viewed. I chose an ad that was apart of a campaign for a swiss Italian ski resort (picture 3). A website was commenting on the success of this ad with the title of the Article ââ¬Å"Lesbians Good for Ski Business. â⬠the comment on this ad stated, ââ¬Å"Seems some brilliant ad agency came up with a campaign to promote the Swiss Italian ski resort Airolo by featuring two women about to kiss (pictured above). Weââ¬â¢re going to hazard a guess that the intended demographic was not lesbians. They were probably targeting lager louts looking for a good stag party getaway now that Prague has kicked them out. â⬠(Get Outdoor Blog) The imagery does not have any clever tagline, or anything to empower lesbains. In fact, one of the main centerpieces of the point of this ad is the male in the background completely enamored and excited by the thought of two girls kissing. The comment on the article even states that ââ¬Å"the intended demographic was not lesbains. â⬠and makes the point that this ad was to promote a party scene. In fact, most viewers probably would not even assume the two girls in the ad as lesbians. By no means does the ad seem to support the gay community, it rather just sexualizes the fantasy of watching two women make out. A sexual lesbian experience can be arousing to straight men and women, conveying a ââ¬Å"partyâ⬠type of experience while if the couple was actually a gay couple about to engage in a kiss, this ad would most likely be only arousing to gay men, and convey the message that ââ¬Å"We are a gay friendly placeâ⬠rather than a ââ¬Å"Party Placeâ⬠. Another advertisement that depicts the sexual objectification of women is the Nikon ad. There is a hand holding up a camera in which he captures the image of two women in lingerie on top of each other. While the gender of the person taking the photo is not identified, it appears to be a male. Because of the interest in the (presumed) male figure, this ad makes it very evident that the relationship between the two women is not a committed lesbian relationship. It is portrayed to be just a sexual one with an objective to please the male. The copy at the bottom states that the Nikon S60 detects up to 12 faces. When you look closer at the ad, you can spot four males in the adjacent apartment building watching the girl-on-girl action. Many consumers were very upset with this ad, believing it to be both sexist and delegitimizing to lesbian relationships. They made the argument that, the advertisement is sexist relies heavily on the notion that the lesbians are unwitting, innocent subjects violated by a voyeuristic male glaze. â⬠(Turnbell) The writer refutes this argument by stating that the two women made the conscious decision to objectify themselves by leaving the curtains open, as well letting another male to capture their (not-so) intimate moment on a camera. Addition ally, the ad is relevant to the product because it successfully communicates in a clever way that that even though the faces are so far away, the camera is advanced enough to still detect the voyeurs faces. Personally, I completely agree with the writerââ¬â¢s argument. However, I would also argue that these types of ads do present a problem to the lesbian community. How can advertisements tastefully depict a lesbian encounter that meaningfully supports and empowers the lesbian community? Also, how can you conveys that the two women are legitimately homosexual, rather than a sexualizing their experience? This objectification of the lesbian relationship is likely why many lesbian advertisements are underrepresented. In general, they are most comfortable to advertisements that use implicit hints of sexuality rather than involving males or females (such as the car commercial). Some argue that ââ¬Å"lesbians are female versions of male sexualityâ⬠, but this argument is scrutinized because lesbians describe their experience to be completely different. Typically, lesbians are more socially accepted than gay males are. However, they have to fight harder to convince society that their identity is more than just a sexual desirability of a female. One company that has successfully done so is JC Pennyââ¬â¢s. In 2012, they released their ââ¬Å"Freedom of Expressionâ⬠ad (See Picture 5) that features two mothers and their daughter. While a group called ââ¬Å"One Million Mothersâ⬠presented backlash to this ad, the overall response was positive. There is no overt sexual nature in this picture, it is just depicting a family photo with two mothers. ââ¬Å"As jcpenney focuses on becoming Americaââ¬â¢s favorite store, we want to be a store for all Americans. In celebration of Motherââ¬â¢s Day, weââ¬â¢re proud that our May book honors women from diverse backgrounds who all share the heartwarming experience of motherhood. â⬠-Eric Bovin (ABC news) In conclusion; advertisers have recognized the great importance of tapping into the gay market. Not only is establishing your company as being in support of this cause positive, but in some markets; it is necessary. Overall, Advertising to the gay and lesbian community is not one-size-fits-all. It are also specific precautions that you must take in entering into this type of market. Not only are you going up against the criticisms of anti-gay groups, but you are also up against the scrutiny of whether your advertisement is legitimate or whether you are using the leverage of the gay community to seem more accepting and grow your consumer base. There are Advertising Agencies must take into account the way in which homosexuals identify themselves in terms of their involvement as well as the how males and females differ in what appeals to them. Works Cited Hilary Chura, ââ¬Å"Coors hikes spending on gay ads, March 27, 2000 Katherine Sender, Business Not Politics: The Making of the Gay Market, New York: Columbia University Press, 2005, 331 pp. , ââ¬Å"The Dynamics of Brand Legitimacy: An Interpretive Study in the Gay Menââ¬â¢s Community (PDF)â⬠. Journal Article, Journal of Consumer Research, University of Chicago Press. JSTOR 10. Going Green, Going Gay? Micheal Koretzky, Jan 13, 2011 The Williams Institute, ââ¬Å"Documented Evidence of Employment Discrimination and Its Effects on LGBT Peopleâ⬠(July 2011). Get Outdoors Blog, ââ¬Å"Lesbians for Good Ski Businessâ⬠(Decemebr 21,2007) James Turnbell, ââ¬Å"A Sexist Advertisement? Lesbians and the Politics of the Male Glazeâ⬠(December 13, 2008) ABC News, ââ¬Å"JC Penney Features Same Sex Couple in May Catalougeâ⬠, (May 12, 2012) How to cite Gay and Lesbian Advertising, Essay examples
Friday, December 6, 2019
Medicinal Chemistry
Questions: 1. Consider, for example, conducting a microbiological assay where inhibition of growth of bacteria is determined when different concentrations of drugs are applied. What factors may lead to variability or errors within the results and how could these variations or errors be minimised?2. Why is it important to have information on physico-chemical properties (such as logarithm of the octanol:water partition coefficient (log P) and log aqueous solubility (log S)) in drug development i.e. what role do these properties play in determining formulation and drug uptake / distribution in the body?3. Is predicting ADME and potential toxicity of drug candidates early in the drug development process important or should the focus of research be to maximise efficacy of the candidate molecules? Your answer should include a discussion of the advantages and limitations of using simple screening tools, such as Total polar surface area (TPSA), violations for Lipinskis Rule of Fives and number of rotat able bonds may be used in screening and normalised occurrence ratios (NORs), potential toxicity and metabolism? Answer: 1. Microbiological assays are mostly conducted in the laboratory to check the bacterial growth inhibition in the presence of different drug concentration. This can be performed in a plates containing growth medium. Zone of equivalence is found within the plates, which represents the concentration at which a particular microbial growth is inhibited by particular drug (Zuccheri and Asproulis, 2012). Various factors may affect the results. These are improper preparation of growth medium, improper selection of the population number, imbalanced moisture, pH, nutrient content of the growth medium. These errors can be minimized by maintaining proper sterile condition during growth medium preparation, correct selection of drug concentration. 2. LogP and logs coefficients are distinguished as the most important parameters for lipophilicity assessment, estimation of chemical compounds solubility and determination of pharmacokinetic properties. Tendency of molecules to get dissolve in lipids is generally calculated as logP. Tendency of molecules to get dissolve in water lipids is generally calculated as logS (Sun, 2004). So, when a drug molecule is developed, it is very much essential to understand the basic property of that particular molecule, whether that molecule will be taken up by the human system and distributed properly within a certain period of time, hence quantification of logP and logs is very much significant. 3. Prediction of absorption, distribution, metabolism and excretion and potential drug toxicity initially during the drug development process is important and the related research focus should be made to maximize the effectiveness of the candidate molecule. This is because it helps in predicting enzyme inhibition, such as: CYP3A4 Noninhibitor, CYP2D6 Noninhibitor, CYP2C19 Noninhibitor, CYP2C9 Noninhibitor, CYP1A2 Inhibitor. Fluvoxamine is a strong CYP1A2 Inhibitor and inhibits some of the cytochrome P450 enzymes, like: CYP3A4, CYP2C9 etc. Thus, fluvoxamine prevents few metabolic pathways from recompensing for CYP1A2 inhibition. This type of enzymatic inhibition or non-inhibition can be predicted with the help of screening tools, which is considered as advantage. Disadvantages may include unrestrained adsorption methods or matrix trapping or covalent bound or immobilization methods, low quantity enzymatic activity along with the limitation of mass transfer. ADME properties include abs orption, distribution, metabolism and excretion and potential drug toxicity and these properties determine the drug disposition once a drug enters into the system. Total polar surface area or TPSA of a candidate molecule is identified as the sum of the surface over polar atoms, for example: nitrogen, oxygen, including attached hydrogens (Chatwal, 2010). TPSA is used to optimize the ability of a candidate drug to permeate cells. Molecules with more than 140 squared are likely to be poor at cell membrane permeation. Lipinskis rule of five evaluates drug-likeliness and find out whether a chemical compound with particular biological or pharmacological activity has characteristic properties, which would make the compound an expected orally active medicine in humans. Mostly orally consumed drugs are comparatively small and lipophilic molecules. The advantage of Lipinskis rule of five is that it illustrates the significance of certain molecular properties for a particular drug pharmacokine tics inside the human system. This includes absorption, distribution, metabolism and excretion. The major disadvantage of this rule is that it does not calculate whether the candidate molecule is active pharmacologically. To predict a candidate molecule, the atomic environment in the candidate molecule is calculated and then database is searched for comparable surroundings. Occurrence ratio measures how often the similar surrounding has been discovered, compared with how frequently it has been found out in total, and then is calculated for individual atom in the candidate molecule (Carlsson et al., 2010). This ratio present comparative probability of metabolism taking place at individual atom but the disadvantage is that it does not predict whether the candidate molecule undergoes metabolism. References Carlsson, L., Spjuth, O., Adams, S., Glen, R. and Boyer, S. (2010). Use of historic metabolic biotransformation data as a means of anticipating metabolic sites using MetaPrint2D and Bioclipse.BMC Bioinformatics, 11(1), p.362. Chatwal, G. (2010).Medicinal chemistry. Mumbai [India]: Himalaya Pub. House. Sun, H. (2004). A Universal Molecular Descriptor System for Prediction of LogP, LogS, LogBB, and Absorption.Journal of Chemical Information and Modeling, 44(2), pp.748-757. Zuccheri, G. and Asproulis, N. (2012).Detection of pathogens in water using micro and nano-technology. London: IWA Publishing.
Friday, November 29, 2019
Wtc Bombing Essays - Manhattan, New York City, Financial District
Wtc Bombing Dear Cobras, As I came out of my Calculus class at exactly 9:10 A.M. on September 11, I witnessed an event that would change my life forever; the attack on the World Trade Center. I was standing on Broadway and 8th street approximately 10 blocks from the New York City Financial District. As I walked outside, I noticed that there were several people not being able to use their cell phones and by nature I proceeded to look around and see what had happened. As I looked up, I saw the second plane hit the south tower of the trade center. I couldnt believe my eyes; the beautiful silver towers of the world trade center were on fire. I stood there to see what else would happen. About ten minutes later, I saw the first tower crumble to its demise. At that point, I was devastated. The landscape I had been so used to was now being destroyed. Although I was ten blocks from the site, the smoke began to engulf all buildings surrounding my area. I began to run to my dorm room in fear of my life. When I finally got to my dorm room, I couldnt believe what had just happened. Although I feared for my safety, I immediately ran to the Red Cross to donate blood because I knew that I was O- and many people would need donations. What I saw there was enlightening; there were hundreds of people lined up to give their blood to others. In only an hour, all these people had gathered. Furthermore, business owners and employees were coming around with water and bread to feed the people standing in line. When I asked if they were part of some group, they said they just came out to help their fellow citizens. It was sensational that in a city known for a cold demeanor and unkind people, people were giving completely of themselves without regard to their own safety. The city had become one, which is what I hope so many people will learn from this tragedy. It was unfortunate that it took a disaster such as this to make people come together. We should learn from this. Immediately after I gave blood I signed u p to volunteer with the Red Cross and State Emergency Relief. Due to my experience with Hurricane Andrew Relief, I was put to work that same day. I was transported at about 6: oo PM to Liberty Place (Ground Zero). I began to help in the Triage Hospital, running blood and supplies to nurses and doctors. It was the most devastation I had ever seen in my entire life. There were so many hurt that there were not enough places to put everyone. I helped put bed sheets on common desk chairs in order to accommodate more victims. These people that like everyone had just gone to work were now sitting bloody and bruised without knowledge of their colleagues or family. Such a common day had changed their life forever. History Essays
Monday, November 25, 2019
Lester Beall essays
Lester Beall essays Lester Beall was one of the most prolific and influential designers of the early to mid-twentieth century. Philip Meggs in his A History of Graphic Design, credits Beall with "almost single-handedly launching the Modern movement in American design." He changed the way graphic design was perceived by people both involved in and outside of the profession. Beall felt that designing something simply to make it visually appealing was j ust not good enough; that design had the higher purpose of being a means to an end, an instrument of communication. He was quoted as saying that the designer "must work with one goal in mind-to integrate the elements in such a manner that they will combine to produce a result that will convey not merely a static commercial message, but an emotional reaction as well. If we can produce the kind of art which harnesses the power of the human instinct for that harmony of form, beauty and cleanness that seems inevitable when you see it... then I think we may be doing a job for our clients." He graduated from the University of Chicago with a bachelors degree in Art History, but as a designer, he was mostly self taught. The influence of European Avant Garde and Bauhaus artists and designers such as Herbert Bayer, El Lissitzky, and Lazlo Moholy-Nagy is obvious in the bright, flat colors and dynamic placement of geometric elements seen in most of his work. This philosophy is most evident in the series of posters Beall did for the U. S. government between 1937 and 1941, especially those for the Rural Electrification Administration, which were designed to encourage rural residents to electrify their homes. The posters display examples of the basic needs of daily rural life, such as light, running water for laundry, farm work, and radio communication stated simply and quietly in slab typefaces and represented by a silhouetted graphic image. This would usually be depicted resting on a flat horizon with brigh...
Thursday, November 21, 2019
Correct assignment 1A Research Paper Example | Topics and Well Written Essays - 500 words
Correct assignment 1A - Research Paper Example ethod to discovering how the human brain and spinal cord function is the only ââ¬Ërightââ¬â¢ way to understand the human nervous system and that this study will lead to 100% understanding of the system. fact, object or phenomenon that is conducted by studying the various intrinsic features or traits of the subject matter and their relation to the world. It is essentially a quest to know the ââ¬Ëtruthââ¬â¢ about the significance of the subject matter. Someone with an idealistic ontology feels that reality is based more in the mind and the spirit instead of the physical and material world. Someone who places more emphasis on the material or physical world as a basis for reality would have a materialistic ontological perspective. Epistemology is the term that refers to the description of the fundamental sources of the development of concepts and human perception and knowledge that helps us to distinguish between the right and wrong and directs our beliefs and actions. In order to consider the sources of knowledge, there follows a debate comparing the rationalism (what seems right) with empiricism (what experience tells). Different people hold different opinions about the same matter because they have had different experiences with it or heard of it differently. This knowledge helps them to shape their approaches, beliefs and actions. We tend to have different opinion about a person until we happen to know him/her better by having a conversation with him/her. This holds true for beliefs also. Methodology is the planned steps that one anticipates making in order to test whether a hypothesis is correct. The methodology can refer to either a qualitative or quantitative analysis of data collected. Methodology is based on the study design adopted for the purpose of conducting the research, and includes data collection, analysis and interpretation. When there is a need to know the studentââ¬â¢s perception about their curriculum in a certain school, a certain number of students
Wednesday, November 20, 2019
Marketing projectthe puzzle phone Essay Example | Topics and Well Written Essays - 1250 words
Marketing projectthe puzzle phone - Essay Example Although there are many other companies operating in the mobile phone industry but in terms of market share iPhone and Samsung are the leading brands. However for surviving in such a competitive market our company is offering some specific features that will help us create product differentiation. Puzz phone is a phone with distinctive, advanced and innovative features at affordable price. Our pricing strategies are very much different from our competitors as we are offering customized products at affordable price. Puzz is also trying to come up with new innovative technological features in order to compete with brands like Samsung. Puzz phone offers more variable features to its customers and that is what will help us to attract new customers. Our company also takes lesser time to assemble customersââ¬â¢ product. There are various factors that are considered to be the strength of Puzz Phone, however the important ones are its price and high customization. We offer variability in price so customers are allowed to choose according to their preferences. The price advantage provided by Rubik incorporation helps attracting a lot of customers. High customization helps customers selecting the features of their own choice. The demand of every customer is different from the other. Puzz phone helps people to express their own different character and personality through their phones. There are some features of the phone that do affect the brand image. These features are the low productivity and efficiency of the phone. The high customization being offered by the company does affect the productivity of the brand. The company however is trying to overcome the drawbacks in order to cater with the complaints of the customers and establish long term loyalty of the customer. Rubik incorporation is also trying to adopt useful marketing strategies for fulfill their mission and vision. The mobile phone industry is considered to be the
Monday, November 18, 2019
Literature critique Essay Example | Topics and Well Written Essays - 1000 words
Literature critique - Essay Example authors get across that the failure to communicate has been shown to be at the root of 60% of events reported to the Joint Commission on Accreditation of Healthcare Organization. Reports from coroners also suggest that error in communication tends to lead to the death of a patient. The title gets straight to the point, informing the audience of the importance of the study. There are ten authors, three as observers, three as analysts, and the other four had roles that were not obvious. The abstract provides the reader with the background, methods, and results of the study. They state a clear objective, nevertheless a rationale is not given at this stage. Also supplied is an overview and summary of the results. The authors have provided a short informative and understandable background of the topic supported by evidences and statistics, including literature and ethnographic findings suggest that the current weaknesses in communication in the operating room may derive form a lack of standardization and team integration. The writers anticipate that a carefully adapted checklist system could promote safer, more effective communication in the operation room team. The literature review was merely a summary, not a review. The aim of the study was to define common communication failures. Some details of participating in the study were included along with an explanation of the data collected, the methods used to record data as well as the procedures for data analysis. According to Taylor and Bodgan (1998) the research design in this study was clearly appropriate to address the research aims. The researchers provide enough details regarding ethical issues. They made it clear that they had taken the necessary approval from the ethical board of the hospital. According to Silverman (2001), ethical issues come first before many other factors in studying subjects on humans. The researchers have explained that 94 team members participated from anesthesia, surgery, and nursing
Saturday, November 16, 2019
Significance of HRM in the travel and tourism sector
Significance of HRM in the travel and tourism sector The purpose of this report is to evaluate the significance of IHRM for the companies within the travel and tourism sector. The report will address this issue with reference to the case of the British Airways Lpc (BA) one of the largest international airlines. The report will begin by outlining the brief overview of BA, its market and current global position. Besides, the significance of culture change within the company will be identified. Furthermore, the hard and soft models of HRM will be critically analysed in the process. The report also will discuss the staffing issues such as recruitment, selection, and training and development for the planned global expansion. The ways in which these issues may need to change will be illustrated through the strategic evaluation. In addition, all figures will be justified and referenced to the appendix. Moreover, the report will outline the appropriate conclusions and recommendations. Company overview, its markets and current global position British Airways Plc (BA) was created in the 1974s after merger between BEA (British European Airways) and BOAC (British Overseas Corporation) (Air flights, 2010). BA is the United Kingdoms major international airline with two main hubs located in Gatwick and Heathrow airports, and the fifth worlds top airline. BA is a recognized brand within airline industry and the success could attribute to its constant global flight expansion and mergers with other global airlines. The merger between Iberia and BA (International Airlines Group) in 2010 is expected to create the third largest European carrier (see Appendix 1). In addition, the merger with AA (American Airlines) in 2008 will expand the company globally on transatlantic flights. These mergers will make stronger the global position of the new company with strong market capitalisation and will be able to complete with rivals such as Lufthansa and KLM-Air France (See Appendix 2) (Datamonitor, 2009; Euromonitor, 2010). BA is a global leader with a network of 550 destinations internationally via code-sharing relationships serves nearly 95 million passengers a year, using 441 airports in 86 countries and approximately 1,000 planes and a world air share of 2.9% (See Appendix 3) (Brave New Talent, 2008-2010; Wikipedia, 2010). BA operates mostly in the EU and US and employs 40,627 people (Datamonitor, 2009). In addition, BA is a part of Oneworld alliance, which serves some 819 destinations worldwide and enables to compete more successfully around the world with other global alliances (Wikipedia, 2010). Since privatisation in 1987, BA has had a sharp success in income and achieved financial independence, while other European airlines were dependent on state support and their US counterparts resorted to bankruptcy protection (Ledwidge, 2007 and BBC, no date). Despite the BAs HR hard times (appendix) and recent global economic recession in 2008/2009 with the global GDP decline from 5.1% in 2007 to 3.1% in 2008 , BA had a net profit of à £8 billion in 2009/2010 that is an increase of 2.7% over FY2008/2009, which improves its stable geographic increase (Datamonitor, 2010). Besides, BA is the worlds first airline to establish a carbon-offset scheme in 2005 to decrease greenhouse gas emissions and to introduce online boarding passes in 2004 (British Airways, no date and AccessMyLibrary, 2007). Despite BA calls itself as The Worlds Favourite Airline it strives to become the worlds most responsible airline (GreenAir, 2007-2010 and Street, 1994). Cultural change and HRM models Culture is very powerful; it influences people and it is vital for managers to understand the employees: what they believe, its customs and traditions, life style and values, beliefs and morals, to understand how people react, and their expectations in the company after the employment. Legge (2005) identifies culture as a set of shared meanings, or taken-for-granted assumptions. According to Alzira and Easerby-Smith (1993), BA was arrogant before its privatization in 1987. BA believed the customers did not know what they wanted. The managers did not involve the staff in decisions, as they wanted to have distance from staff. The priority was safety of aircrafts and technical skills. Even the competition and profitability were not the main idea. The BA organisational culture was bureaucratic, strict, and formal. Thus, the careers developed slowly. Besides, the cost-leadership strategy is applied that leads BA to cut costs through a hard HRM approach and use staff as any other business resource. The staff is being used as cheaply as possible. In contrast, Ledwin (2007) argues that since 1976 till nowadays it was a big cultural change for BA, where the product-centric approach has started to shape into customer-centric approach and the hard model started to adopt the elements of soft developmental humanism or Harvard model, where the core idea are human assets. The differentation strategy would reach the competitve advantage and try to avoid less prone to disruptions and PR blunders. Moreover, it would present a very effective framework for completely integrating HR with the business strategy (Ledwin, 2007). To improve the organisational performance and to achieve the employee commitment BA promoted the motivational culture change programmes in the 1980s.However, its argued if these programmes were successful or not as according to Hopfl (1992, cited in Legge, 2005), these programmes engaged the mind but left hearts untouched. Despite the HR difficulties during the last five years (See Appendix 4), the company has achieved a respect from its employees in a way that helps the company fence the strike actions. In June 2009, BA told its 42,377 staff to work without pay for a month or take unpaid leave to reduce costs. Almost 6,000 non-cabin crew staff helped during the days of industrial action helped the company to run anoperation (Euromonitor, 2010 and Anglotopia, 2010). Staffing approaches BA can apply one of the three staffing approaches (Dowling et al., 2008): Ethnocentric:- The main idea is to manage staff from the home country (PCNs). The company can apply this approach to all its foreign operations, where the staff holds central jobs, and subsidiaries and headquarters follow the home country resource management practice. Polycentric/Regiocentric:- The idea is to develop HR management practices locally. Geocentric/Global:- The purpose is to manage the employees on a worldwide basis, where the company employs staff from diverse countries. 4.1. Ethnocentric and polycentric approaches BA uses mainly the ethnocentric approach: it controls all its operations from London (the locations of the head office) as it understands local culture, the economy language and avoids relocation costs. Regarding to BA job applications, the key management positions are filled by parent company personnel, where the priorities are given to UK nationals. Besides, it hires host country nationals in foreign countries instead of transferring its domestic staff to work. Depend on the staff role, a polycentric or geocentric approach can be recommended. The polycentric approach would be ideal for BA to employ front line staff and cabin crew. The company should consider the cultural as the core competence and hire more people who speak other languages than English and think differently. Along with the cultural change BA needs to ensure the employees understand their role within the marketing progress and overall marketing orientation within the organization. The best staffing approach to hire key management people and pilots is geocentric approach, where the company strives to reach the global expansion by combining the best from headquarters and the subsidiaries. Also, the nationality is ignored in favor of ability. BA could promote promote diversity, inclusion, and equality of opportunity in employment regardless of sex, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origins, sexual orientation, disability, religion or belief, political affiliation and age (British Airways, no date). Staffing issues The organisations stage of growth characterises with the integration of business strategy with HRM policies such as training development, appraisal and recruitment and selection. Recruitment is mailny linked to proactive attitude of employees, where training and development has to do with formal or informal education, enabling the staff to know inside out of the organisational mission and its products, thus leading to the quality service. 5.1Recruitment and selection Effectiveness in recruitment and selection is vital as it avoids poor work performance, unacceptable conduct, internal disagreement, low morale and job satisfaction and dysfunctional labour turnover. In addition, luck of management quality and teamwork, and employee motivation and communication can lead to loss of customers, loss of organisation, and loss of life. Recruitment seeks to attract best technical professional talent and then manage rapid internal labour market movements (Legge, 2005:142). BA also tends to attract the most talented people, then assess and appoint a suitable candidate (Appelbaum and Brenda, 2002; Pilbeam and Corbridge, 2006). For example, the pilots employment issues had been based just on flying and technical skills before 1987. Nowadays, BA considers the pilots can work well in a crew situation. Interpersonal skills are appearing as crucial achievement factors for pilot performance and safety. In addition, it cares about quality frontline people as well. G ood (1999, cited by Appelbaum and Brenda, 2002), stresses the point that the single most reliable predictor of overall excellence is the ability to attract and hold on to talented employees. The success is dependent upon the ongoing hard work, attitudes, and dedication of its staff. Thus, to expand globally and to achieve the companys long-term success BA should look not only at education related skills but also at staff attitude within the company, as skills can be trained but attitudes cannot be changed (Milmo, 2010 and Horn and Barkin, 1998). 5.2Appraisal, training, development The globalisation of markets leads to emergence of multinational companies, operating on a worldwide basis. Good training enables the employees to perform their current and future roles effectively as, both organisations and their employees benefit (Beardwell and Claydon, 2006). To achieve a high value added services the staff should be well educated, trained, and committed. To increase competence and go high-class with high quality the company should consider the staff as the most valued resource and do investment in the core workforce. The accent is to include employee loyalty and reliance, internal labour market structures with promotion ladders and skill training. The individualistic approach should be applied to reach the quality and competitive advantage (Legge, 2005). If the quality of service depends on the quality of the employee, the company should look on the society and organisations commitment to developing skills appropriate to a national economic policy and organisational corporate objectives (Legge, 2005). BA committed to customer care programmes and has had many motivational staff programmes for both existing and newly recruited staff since 1987, that at very least heightened employee awareness of quality issues. The programmes such as Putting the Customer First,Putting People First, Customer First teams, Managing People First, A Day in the Life, To be the Best and Winning for Customers . In addition, to promote the values of customer services BA launched the re-educative online-learning programs for cabin crew how to teach in-flight sales system. Besides, BA tried to develop a self-direct learning that motivates and develops its staff not only professionally but personally (Ledwidge, 2007). Conclusion The report began with a brief nature of British Airways, overview of its markets and current global position. It analysed the cultural change within the company and evaluated the HRM models. BA has had a big cultural change since 1987, where the company changed the product-centric approach to a customer-centric approach. The hard model need to adopt elements from the soft developmental humanism model, where the company would realize the importance of integrating HR policies with business objectives involving treating employees as valued assets, as the success depends on securing commitment from people, not controlling them. It should keep adopting the soft model to avoid losses of customers and the bankruptcy and to keep its brand. Over the past decade or so, British Airways has evolved from a loss making, state-owned national carrier into a customer focused, publicly listed and consistently profitable airline. However, cultural change and nowadays change require modification in top management values to make the change successful. To improve the organisational performance and keep the company expand globally BA need to keep these recent changes. Furthermore, the report addresses the issue of staffing approaches such as ethnocentric, polycentric, and geocentric approaches. Despite BA uses the ethnocentric approach, the recommendation are to develop polycentric approach for front line and cabin crew and apply a geocentric approach for pilots and key management staff. The final parts of the report examined the staffing issues such as recruitment and selection, appraisal, training and development. BA should look not only at education related skills but also at staff attitude within the company, as skills can be trained but attitudes cannot be changed. In addition, BA should motivate and develop its staff not only professionally but personally by creating the training centres where staff could learn the sense of humour, ability to work with others and friendliness. Moreover, the new industrial relations backgrounds should be developed as no-strike clauses, acceptance of flexible working, its support for direct employee involvement, staff status and employee development Recommendations According to the mentioned above issues, there is more research should be done regarding to staffing approaches and staffing issues to help expand company globally. The need of change should be analyzed and evaluated deeper. HRM Michigan and Harvard models issues should be more critically discussed. Word count: 2193 word
Wednesday, November 13, 2019
Reflexive Substantion of an One-Way Ascendancy of Mathematics over Ethics :: Mathematics Math Papers
Reflexive Substantion of an One-Way Ascendancy of Mathematics over Ethics ABSTRACT: Russell and Popper are concordant with Plato with respect to the independence of mathematics upon the sensations. Beth shares the opinion of the complete independence between the world of science and mathematics and that of psychology. Essenin-Vol'pin's opinion is of an ascendance of ethics and jurisprudence over mathematics. For the first time, the position of Plato, Russell, and Popper are substantiated in this paper through Hegel's reflexive natural scientific method. The external activation of numbers into interaction through arithmetical operations, adopted by him, has been taken as a basis of this substantion. This is the reason why mathematical rules of reasoning are exact-they represent a pure product of the 'third world.' The rules of ethics and the related humanities are their reflective approximate reverberations. Ascendancy of the rules of such types of science over mathematics is impossible due to the irreversibility of the reflexion. The problem of the interaction between the psychical and the thinking worlds as reverberations of the material one has been treated much earlier by ancient philosophy. Plato excludes any dependence of mathematics, it being the most brilliant representative of the mental world, of the sensations. Russell [1] (I. pp. 237-238) is concordant with the above. He considers that the mathematical truth is "applicable solely to the symbols," the symbols being "words," that "do not signify anything in the real world." Thus, the correct opinion, pointed out, remains unsubstantiated, since nowhere is it related to the philosophical categories. In the substantion, offered by this paper, we proceed from the assumption that the variety of the mathematical symbols, at any rate, is reduced to and ensues from the aim: namely-to study the quantitative characteristics of "the qualities" from "the being." That connects the mathematical symbols with "the real world," i.e.-it reveals the possibility of a substantiating, since those characteristics interact. Following the construction of the foundations of mathematics, we should agree that the interaction among its concepts (i.e. the rules of the mathematical reasoning) is reduced to the interaction among the natural numbers. Hegel defines them reflexively [2], [3] ensuing from "the qualities" of "the beig" which (conversely) indicates that the mathematical truth denotes something "in the real world." Russell has pointed out that "Hegel's philosophy is very difficult-he is ...the most difficult to grasp of all great philosophers" [1] (III., p. 337), thus associating him with the philosophers "willing to spread confusion in mathematics" [1] (III. Reflexive Substantion of an One-Way Ascendancy of Mathematics over Ethics :: Mathematics Math Papers Reflexive Substantion of an One-Way Ascendancy of Mathematics over Ethics ABSTRACT: Russell and Popper are concordant with Plato with respect to the independence of mathematics upon the sensations. Beth shares the opinion of the complete independence between the world of science and mathematics and that of psychology. Essenin-Vol'pin's opinion is of an ascendance of ethics and jurisprudence over mathematics. For the first time, the position of Plato, Russell, and Popper are substantiated in this paper through Hegel's reflexive natural scientific method. The external activation of numbers into interaction through arithmetical operations, adopted by him, has been taken as a basis of this substantion. This is the reason why mathematical rules of reasoning are exact-they represent a pure product of the 'third world.' The rules of ethics and the related humanities are their reflective approximate reverberations. Ascendancy of the rules of such types of science over mathematics is impossible due to the irreversibility of the reflexion. The problem of the interaction between the psychical and the thinking worlds as reverberations of the material one has been treated much earlier by ancient philosophy. Plato excludes any dependence of mathematics, it being the most brilliant representative of the mental world, of the sensations. Russell [1] (I. pp. 237-238) is concordant with the above. He considers that the mathematical truth is "applicable solely to the symbols," the symbols being "words," that "do not signify anything in the real world." Thus, the correct opinion, pointed out, remains unsubstantiated, since nowhere is it related to the philosophical categories. In the substantion, offered by this paper, we proceed from the assumption that the variety of the mathematical symbols, at any rate, is reduced to and ensues from the aim: namely-to study the quantitative characteristics of "the qualities" from "the being." That connects the mathematical symbols with "the real world," i.e.-it reveals the possibility of a substantiating, since those characteristics interact. Following the construction of the foundations of mathematics, we should agree that the interaction among its concepts (i.e. the rules of the mathematical reasoning) is reduced to the interaction among the natural numbers. Hegel defines them reflexively [2], [3] ensuing from "the qualities" of "the beig" which (conversely) indicates that the mathematical truth denotes something "in the real world." Russell has pointed out that "Hegel's philosophy is very difficult-he is ...the most difficult to grasp of all great philosophers" [1] (III., p. 337), thus associating him with the philosophers "willing to spread confusion in mathematics" [1] (III.
Monday, November 11, 2019
Deception in ResearchÃÂ
Deception in Research The article I chose from Capella Library was about Deception in Research. While exploring my area of interest may require misleading or not completely informing your subjects about the true nature of your research, as a general rule, serious deception should be avoided whenever possible, since it put at risks the integrity of informed authority. For research involving deception the use of deception must be justified in the procedure to show that the research cannot be performed in the absence of deception and the benefits of the research will sufficiently be more important than any risks that deception may create.Research participants cannot be deceived about significant aspects of the research that would affect their willingness to participate or that would cause them physical or emotional harm. Deception must be explained to participants (debriefed) as early as reasonable. A debriefing script must be included in the procedure and should include a detailed desc ription of the ways in which deception was used and why; when and by whom the debriefing will be administered should also be included.True ââ¬Å"informed consentâ⬠cannot be given if the true nature of the research is deceptively presented. This situation is dealt with administratively via a waiver of portions of the information consent regulations. Deception is a word used to end arguments, not to begin them. To accuse researchers of deception is to remove them from the ranks of those with whom legitimate human relationships can be pursued. For an example, letââ¬â¢s look at in the article of Deception in Research on the Placebo Effect.Experiments exploring the placebo effect, however, suggest justifiable ethical concerns, owing to the use of deception. The ethical intend to conduct of deceptive placebo research include (1) review and approval by an independent research ethics to establish the use of deception and that the study protocol offers sufficient value to justify t he risks it poses to participants, including the use of deception; (2) disclosure in the informed-consent document that the study involves the use of deception; and (3) participants at the conclusion of research participation.This also concludes that in order to supply to public accountability, articles reporting the results of research using deception should describe temporarily loyalty with these participant-protection rules. Ethics is one of the most crucial areas of research, with deception and research increasingly becoming a crucial area of discussion between psychologists, philosophers and ethical groups.Examples of Deception and Research to show how ethical concerns have changed during the 20th century, it is useful to look at some examples such as Deception in Psychological Research. Deception has been attacked repeatedly as ethically unacceptable and morally reprehensible. However, research has revealed that subjects who have participated in deception experiments versus no deception experiments enjoyed the experience more, received more educational benefit from it, and did not mind being deceived or having their privacy invaded.Such evidence suggests that deception, although unethical from a moral point of view, is not considered to be aversive, undesirable, or an unacceptable methodology from the research participant's point of view. The repeated assumption of the unacceptability of deception seems to be due to the fact that deception has been evaluated only from the viewpoint of moral philosophizing. This has led to the repeated conclusion that deception is reprehensible and seems to have created a perceptual set to view deception immediately as aversive.However, the perception of the unethical nature of deception seems to be minimal in studies that investigate innocuous public behaviors and enhanced in studies that run the risk of harming research participants or in studies that investigate private behaviors. When this knowledge is combined with t he fact that research participants do not mind being deceived, and that it can also be viewed as immoral not to conduct research on important problems, the scale seems to be tilted in favor of continuing the use of deception in psychological research.Is it ethically permissible to use deception in psychological experiments? We argue that, provided some requirements are satisfied, it is possible to use deceptive methods without producing significant harm to research participants and without any significant violation of their autonomy. We also argue that methodological deception is at least at the moment the only effective means by which one can acquire morally significant information about certain behavioral tendencies. Individuals in general and research participants in particular, gain self-knowledge which can help them improve their autonomous decision-making.The community gains collective self-knowledge that, once shared, can play a role in shaping education, informing policies a nd in general creating a more efficient and just society. Reference: 1. Deception in Research on the Placebo Effect Franklin G Miller,*à David Wendler, andà Leora C Swartzman Author informationà Copyright and License informationà See ââ¬Å"Placebo: Physician, Heal Thyselfâ⬠, e388. This article has beenà cited byà other articles in PMC. 2. Harrington A, editor. (1997) The placebo effect: An interdisciplinary exploration.Cambridge (Massachusetts): Harvard University Press. 272 p. 3. Deception in psychology: moral costs and benefits of unsought self-knowledge. Bortolotti L, Mameli M. SourcePhilosophy Department, University of Birmingham, Birmingham, B15 2TT, 2006 Jul-Sep;13(3):259-75. 4. 2002;12(2):117-42. Deception in research: distinctions and solutions from the perspective of utilitarianism. Pittenger DJ. Source Department of Psychology, University of Tennessee at Chattanooga, 615 McCallie Ave. , Chattanooga, TN 37403, USA
Saturday, November 9, 2019
Free Essays on Airbus
The Airbus story Since the 40s, the US monopoly is due to the symbiosis between government and industry regarding civil projects during and after the Second World War. Boeing, Lockheed and MacDonnell Douglas dominated the whole business, supported by various government agencies with substantial funding for research and development. While European airlines are operating 25 percent of the global airline fleet, the European aircraft manufacturer' share of the global market only amounts to ten percent. 85 percent of all commercial aircraft are made in the United States; five percent are built in the rest of the world. In de mid of 60s, it becomes more and more urgent for the industrial decision-makers to react face to this situation and French and British governments are aware of the dangers of the US dominance. So, they recognised that the path of avoiding a US monopoly can only lead to inner European co-operation. First contacts between the British Aircraft Corporation (BAC), Hawker Siddeley Aviation and the French Aviation Industry, North-Aviation, Breguet Aviation and Avions Marcel Dassault are made. Finally, the HBN group is being formed with Hawker, Breguet and North Aviation. In the following time, French and British designers start to develop five design studies. At the same time, the "Arbeitsgemeinschaft Airbus" (working group Airbus) is founded in Germany. Signing a contract on December 23, 1965 ATG Siebel werke, Bolkow, Dornier, Flugzeug-union Sud, HFB, Messerschmitt andVFW commit themselves to be national partners in any future European program which is concerned with technology in the aviation industry.... Free Essays on Airbus Free Essays on Airbus The Airbus story Since the 40s, the US monopoly is due to the symbiosis between government and industry regarding civil projects during and after the Second World War. Boeing, Lockheed and MacDonnell Douglas dominated the whole business, supported by various government agencies with substantial funding for research and development. While European airlines are operating 25 percent of the global airline fleet, the European aircraft manufacturer' share of the global market only amounts to ten percent. 85 percent of all commercial aircraft are made in the United States; five percent are built in the rest of the world. In de mid of 60s, it becomes more and more urgent for the industrial decision-makers to react face to this situation and French and British governments are aware of the dangers of the US dominance. So, they recognised that the path of avoiding a US monopoly can only lead to inner European co-operation. First contacts between the British Aircraft Corporation (BAC), Hawker Siddeley Aviation and the French Aviation Industry, North-Aviation, Breguet Aviation and Avions Marcel Dassault are made. Finally, the HBN group is being formed with Hawker, Breguet and North Aviation. In the following time, French and British designers start to develop five design studies. At the same time, the "Arbeitsgemeinschaft Airbus" (working group Airbus) is founded in Germany. Signing a contract on December 23, 1965 ATG Siebel werke, Bolkow, Dornier, Flugzeug-union Sud, HFB, Messerschmitt andVFW commit themselves to be national partners in any future European program which is concerned with technology in the aviation industry....
Wednesday, November 6, 2019
Napalm and Agent Orange in the Vietnam War
Napalm and Agent Orange in the Vietnam War During the Vietnam War, the United States military used chemical agents in its fight against Ho Chi Minhs Army of North Vietnam and the Viet Cong. The most important of those chemical weapons were the incendiary napalm and the defoliant Agent Orange. Napalm Napalm is a gel, which in its original form contained naphthenic and palmitic acid plus petroleum as fuel.à The modern version, Napalm B, contains plastic polystyrene, hydrocarbon benzene, and gasoline. It burns at temperatures of 800-1,200 degrees C (1,500-2,200 degrees F). When napalm falls on people, the gel sticks to their skin, hair, and clothing, causing unimaginable pain, severe burns, unconsciousness, asphyxiation, and often death. Even those who do not get hit directly with napalm can die from its effects since it burns at such high temperatures that it can create firestorms that use up much of the oxygen in the air. Bystanders also can suffer heatstroke, smoke exposure, and carbon monoxide poisoning. The US first used napalm during World War II in both the European and Pacific theaters, and also deployed it during the Korean War. However, those instances are dwarfed by American use of napalm in the Vietnam War, where the US dropped almost 400,000 tons of napalm bombs in the decade between 1963 and 1973. Of the Vietnamese people who were on the receiving end, 60% suffered fifth-degree burns, meaning that the burn went down to the bone. Horrifying as napalm is, its effects at least are time-limited. That is not the case with the other major chemical weapon the US used against Vietnamà Agent Orange. Agent Orange Agent Orange is a liquid mixture containing the 2,4-D and 2,4,5-T herbicides. The compound is toxic for only about a week before it breaks down, but unfortunately, one of its daughter products is the persistent toxin dioxin. Dioxin lingers in soil, water, and human bodies. During the Vietnam War, the US sprayed Agent Orange on the jungles and fields of Vietnam, Laos, and Cambodia. The Americans sought to defoliate the trees and bushes, so that enemy soldiers would be exposed.à They also wanted to kill off the agricultural crops that fed the Viet Cong (as well as local civilians). The US spread 43 million liters (11.4 million gallons) of Agent Orange on Vietnam, covering 24 percent of South Vietnam with the poison. Over 3,000 villages were in the spray zone. In those areas, dioxin leached into peoples bodies, their food, and worst of all, the groundwater.à In an underground aquifer, the toxin can remain stable for at least 100 years. As a result, even decades later, the dioxin continues to cause health problems and birth defects for Vietnamese people in the sprayed area. The Vietnamese governmentà estimates that about 400,000 people have died from Agent Orange poisoning, and about half a million children have been born with birth defects. US and allied veterans who were exposed during the period of heaviest usage and their children may have elevated rates of various cancers, including soft tissue sarcoma, Non-Hodgkin lymphoma, Hodgkin disease, and lymphocytic leukemia. Victims groups from Vietnam, Korea, and other places where napalm and Agent Orange were used have sued the primary manufacturers of these chemical weapons, Monsanto and Dow Chemical, on several occasions. In 2006, the companies were ordered to pay US$63 million in damages to South Korean veterans who fought in Vietnam.
Monday, November 4, 2019
Developments in technology Essay Example | Topics and Well Written Essays - 1500 words
Developments in technology - Essay Example Due to this, people all over the earthââ¬â¢s surface irrespective of where they are located can communicate with each other just as if they are actually exchanging experiences in a close platform. A person located several kilometers away from the other can just reach another very far away from him or her by simply pressing a single button on a communication garget. This has been enabled by the recent developments in wireless communications enabling people can connect to each other through a wireless medium. The wireless communication system has come a long way and has still a long way to go given the numerous discoveries made every day in the communication and information sector. Arguably this system has come a long way from the period of the wired communication channels where the wired telephone systems were used to the recent developments in mobile communication systems. This paper will look at the recent developments in communication systems and its applicability in the passing of information and communication systems between people in separate locations across the globe. Turkle raises a quite a number of ways in which technology has been helpful to people in the present times. A wide range of benefits are discussed in her research which are of course the actual happenings in the world of wireless communication and information. . However a number of openings in areas where we have applied technology in carrying out various things in our daily lives as we go about doing our duties and which needs to be addressed. Among of these areas include the education field where technological use has had a profound positive impact in shaping the way people acquire education and knowledge. As we speak, there are a number of students around the world who are doing their studies online. The advent of distance learning has come into the setting as a result of the developments in technology and to facilitate the ease in exchanging information on the internet further expand ing the information and communication sector (Clemons and Weber). One can listen to a lecture while doing some other things or carrying out his or her office mandates without any interruption. Besides, just by a single stroke of the keys on the computer keyboards or a single click on any icons on the computer, one is able to attend a lecture taking place several kilometers away from his or her location. Consequently, a lecturer needs not to actually be present in class every day to teach his or her students as this can be done online by connecting the class to an online location where the lecturer in actually located. From this remote location, the lecturer can teach and the students listen, see whatever is being taught as well as take notes and ask questions where necessary ad later on do the exams and submit their papers online. Besides, if you want to consult a source locate I a remote location on some assignments given in class, you donââ¬â¢t necessarily need to go to the lib rary or go shopping for the book in a far off book shop. All that you need is to have an online access to the library and access the book from the library shelves, read it and extract the information required just from your desk hence bringing learning closer to where we are at any moment. To this extent therefore technological developments have greatly made it easier for people all over the world to gain knowledge. Besides all these, technology has also
Saturday, November 2, 2019
Can literature tell the truth better than other arts (Theory of Essay
Can literature tell the truth better than other arts (Theory of knowledge) - Essay Example Some novels are good, some are terrible. The same can be said of other art forms as well. Many paintings are really boring to look at, others you can't stop looking at them. Perhaps it is best to compare the best of novels with the best of other arts. That way the comparison will be more fair and people can see what really happens. Literature are made up of novels and non-fiction works. A novel is very good at getting the reader inside the head of the people who are involved. For example, in the Harry Potter books, the author lets the readers know what Harry is thinking. If you compare this to the films of the books, in the films you don't know what people are thinking. But in the films you see the action better. So when you see Harry on his broomstick attacking a dragon that is better when you see it then when you read it in the book. Films show action better than novels but also are more simple. Novels are much longer and can include more details than a film. A film tends to make things simple for the audience. A novel also takes longer to read than a film takes to watch. A person can read two days today but thirty pages tomorrow. They can then leave the book for a month without reading it at all. So a book is the kind of art that you can take at your own pace. Other arts need to be seen all at once. This is especially the case with a film. You can't really watc five minutes one day, thirty the next and then leave it for a month before watching the rest. It would not seem to make sense. A painting, like a film, shows things rather than tells us about them. It is a picture rather than words. A painting just shows one thing, or set of things, while a novel can tell a whole story of a person or many different generations. The fact that the picture is simple makes it easier for the person who is looking at it to understand what is happening. A sculpture is like a picture in that it shows a particular scene, and only one. The sculpture is different than either novels or films because it is very physical in nature. Some sculptures, as long as they are not too famous, can actually be touched by a person looking at them. You cannot touch a novel or a film. A sculpture can be looked at from different angles, while a novel can only really be read in one way. If you look at a sculpture from behind it will look different from in front. But it will be the same sculpture. Is this a better view of the truth than can be found in novels In one way, yes, because it is like reale life. For example, if you meet someone for the first time you can look at them from the front or from the behind. There are different angles. This is the same with sculpture. Theatre is a bit like sculpture, except it uses real people. You actually see real people in theatre, unlike in film where they are just light on a screen. That makes it different. Different because you can tell that they are real people on the stage. Every performance will be different. A novel is always the same, as is a film. Poetry is an art that is like literature more than the other artes. This is because it uses words, like the novel. The only way a person can understand poetry is to read it. The poem is different from a novel in the fact that it is rather much shorter. You can read most poems in a few minutes. In one way this is like looking at a painting, or, to less extent, a film. Some poetry can be very difficult to read, even
Thursday, October 31, 2019
Trade commission Essay Example | Topics and Well Written Essays - 1000 words
Trade commission - Essay Example Mr. Clark is tied down by his Ph.D. studies. His quality time given to accomplish assigned tasks is reduced. Further, Mr. Clark has trouble prioritizing his job responsibilities. Mr. Clark prioritizes the Economics seminars over his responsibility in the company. He prioritizes making and attending arrangement of the Economistsââ¬â¢ Association. Consequently, he cancels meetings with the Consul-General. Mr. Clark should be held accountable for his actions. Delegation does not absolve Mr. Clark of his responsibilities, as superior (Rees & Porter 116). Mr. Clark does not resolve Mr. Allenââ¬â¢s overburdened job responsibilities. One reason for the excess job responsibilities is Mr. Allenââ¬â¢s marriage to a local resident. Mr. Allenââ¬â¢s expertise in the local language gives Mr. Allen an added advantage. Because of Mr. Allenââ¬â¢s mastery of the local language, Mr. Clark assigns Mr. Allen to handle all local enquiries. Consequently, Mr. Allen communicates and enters int o agreements with all business contacts. Further, Mr. Allen helps Mr. Briggs craft reports to the Ministry of Commerce, during the first few months of Mr. Briggs arrival in the country. Mr. Clark should be made accountable for the effects of Mr. Allenââ¬â¢s overburdened responsibilities. Mr. Allenââ¬â¢s work overload results to delays and poor quality work outputs. Mr. Allen actually handled Mr. Briggsââ¬â¢ work, a new employee. Mr. ... Many very important persons and businessmen with significant relationships were invited. However, the original list of visitors was reduced from 50 to 30 invited guests. Miscommunication will trigger dissent among peers. Second, Mr. Clark should be made accountable for not involving his assistants in the transfer design of the whole government office (including the Consul-Generalââ¬â¢s staff) to a modern commercial building. When Mr. Clark was away for a two-week holiday, nobody could follow up important business matters because neither Mr. Allen nor Mr. Briggs knew what kind of wood and carpet colour Mr. Clark preferred. Consequently, the office decoration work was stopped until Mr. Clark returned for work. Third, Mr. Clark should be made accountable for the confusion cropping up regarding the use of the companyââ¬â¢s official car. The Commission has a Mercedes Benz, which both Mr. Allen and Mr. Briggs is also entitled to use. However, Mr. Clark likes to ask the driver to wait for him at l0.00 am every day where Mr. Clark resides. This meant that either the Assistant Trade Commissioners also have to wait inside the official car for him or they have to proceed to the Commission by other means of transport. Both Mr. Allen and Mr. Briggs felt that they were refused some of their entitled benefits. Further, Mr. Clark must be accountable for abuse of official time. Mr. Clark wrongly prioritised the Ministerââ¬â¢s needs over official needs. When the Ministerââ¬â¢s family visited the city, Mr. Clark put aside his work. He spent two days accompanying them shopping around. Occasionally, when Mr. Briggs calculated the balance of the Commissionââ¬â¢s account, he found that Mr. Clark had bought meals for his friends and family and debited
Tuesday, October 29, 2019
Fitzgerald the Misogynist Essay Example for Free
Fitzgerald the Misogynist Essay At first, the female characters in Fitzgeralds The Great Gatsby seemed to be rather dissimilar. Daisy was the angelic and innocent beauty, Jordan was the androgynous golfer, and Myrtle was the sensuous and vivacious seductress. One was from the holy heavens above, another from the sinful depths below, and the last from the neutral in between. Seems like a good balance, however, as the story progresses, we see more and more that the angle is a fallen one, and that the human is a demon in disguise. All three women in this novel use men in some form to get what they want. Looking at the depictions of the female sex in this novel, I believe that, yes, Fitzgerald was a misogynist. Daisy is a careless siren who uses everything given to her by birth to win what she loves, namely attention, adoration, and social status. The only thing that will give her the three is wealth, and the only thing that can give her wealth is Tom Buchanan. Despite having supposedly change her mine (Fitzgerald 74) just prior to their wedding, Daisy still married Tom Buchanan without so much as a shiver (75), and very eagerly uses her new-found money and power to buy her way to the top. It is evident that, from Daisys point of view, true love cannot compare to the money and adulation she craves. Upon her reunion with Gatsby, the first in five years, she breaks down into tears because shes never seen suchbeautiful shirts before (89). The beautiful shirts owned by Gatsby have proven to Daisy that he is even wealthier than Tom, and this fact sends Daisy into a deep lament. That is, if she had just stayed with Gatsby from the beginning, shed be receiving even more attention and adoration than the already considerable amount she possesses at present because Gatsby could have offered her even more than the immense fortune she already holds. Poor, poor girl. Jordan is the least female of the three females, and I believe this is the reason why Fitzgerald did not have her meet an untimely death, destroy familial relations, or come to any other end she could have at the mercy of a woman-hater. Jordan is representative of the wives and daughters who emerged from WWI as androgynous, self-esteemed, and slightly misandric new women. When Nick first meets Jordan, she was perceived as balancing something on it [her chin] which was quite likely to fall (14). Though it isà not directly stated, I think Jordan is balancing men on her chin. New women like Jordan dont need men, and thus they must use men to prove just that. Myrtle is the home wrecker of the novel. As a direct result of her affair with Tom, she gets herself killed, which leads Wilson into shooting Gatsby, which obviously puts an end to the Gatsby and Daisy affair, the result of which leaves Nick disgusted and breaks it off with Jordan. Besides ruining the lives of everyone around her, Myrtle also meets the most tragic end of all the females in the novel. She is killed on impact in a gruesome car accident, while both Daisy and Jordan are at least left with the prospect of a fresh start. I believe this is because Myrtle is the most feminine of the three. Nick describes her as sensuous, and despite possessing no facet or gleam of beauty, there was an immediate perceptible vitality about her as if the nerves of her body were continually smouldering (28). If Fitzgerald was not a misogynist, then how could someone whose vice is simply being too much of a woman deserve an end as graphic as a left breast hanging loose like a flap (131)?This nove l is certainly not one of happily ever afters, and I believe the fact that women are portrayed as the causes of all the tragedies within this novel is reason enough to proclaim Fitzgerald as a misogynist.
Sunday, October 27, 2019
Permeability of Plasma Membranes
Permeability of Plasma Membranes Introduction Plasma membranes are bi-layered membranes made up of amphiphillic molecules (having charged polar heads tending to be hydrophillic and uncharged fatty acid tails tending to be hydrophobic) that selectively allow entrance of certain large molecules into the cells cytosol and through which water and small non-polar molecules may freely diffuse. This experiment seeks to understand limited aspects of the permeability of the plasma membrane using the Elodea leaf membrane as model organism. Some of the factors upon which permeability of the plasma membranes of biological organisms depend are differences in pH on opposite sides of the membrane, temperature, osmolarity, expression of certain membrane receptors and the concentration gradients of various molecules. This experiment is very limited in scope and seeks to answer only the question of what is the time dependence for permeability of glycerol through the cell membrane. Other experiments have answered many of our questions regarding this and have resulted in mathematical equations describing these results. This experiment will use one of the formula derived from these prior experiments, the Ether:Water partition coefficient for alcoholsiii as a means of hypothesizing what the outcome of this present experiment will be. I have hypothesized that within seconds of exposure to a 0.3M (molar) hyper-tonic solution of glycerol, dissolved in an isotonic deionized water (dH2O)/sucrose solution, the Elodea leaf will plasmolyze irreversibly-an assumption I believe is supported by the fact that glycerols ether:water partition coefficient is only 0.00066iii. Further support for this supposition is the fact that glycerol has a relatively bulky chemical structureviii-owing to its three large, highly polar hydroxyl groups-and a large molecular weight of 92.0938 grams per mole. Alternatively, it may be hypothesized that the glycerol-being an aliphatic alcohol (see diagram in section IV(i) infra) which, itself makes up a part of the plasma membranevi-will be capable of more easily diffusing across the plasma membrane as compared to the sucrose, which cannot diffuse across the membrane, in which case not only will there be no severe plasmolysis but there may, instead, be a build up of turgor pressure inside the cell due to the inward movement of the alcohol and its confinement in the central vacuole. Methods In order to discover what molar concentration of sucrose will be needed in an aqueous solution to create a solution that is isotonic to the leafs cytosol I shall perform a bifurcated experiment in which the first part shall be to determine this concentration. Part two of this experiment will be to determine the period of time it takes for glycerol to diffuse across the plasma membrane. In order to determine which molar solution of sucrose is isotonic to the cytosol of the Elodea cell I labeled 6 micro-centrifuge tubes with the markings: 0.2M, 0.3M, 0.4M, 0.5M, 0.6M and isotonic respectively and using an adjustable pipette placed 1000 ÃŽà ¼L of premixed sucrose solution of each of the indicated molarities into the respective tubes. In each of these tubes I placed an Elodea leaf and allowed them to sit for approximately five minutes [my observations of plasmolysis along with photographs of leaves in similar states to what I observed are provided in table 2 of the Table of observations of plasmolysis and photographs #2-#6 in the Photograph table which can be found in sections III(A) (B) respectively.] While awaiting the leaves to finish soaking I viewed a dry mounted Elodea leaf under a microsocpe using 20X and 40X objectives with 10X ocular so as to have a better idea of what a normal Elodea leaf looks like for comparison to the viewing of the wet mounts [photo of a leaf in similar state to what I observed is provided as photo #1 in the Photograph table of section III(B).] I then labeled 6 microscope slides using the same concentrations I used when labeling the micro-centrifuge tubes. After five minutes I prepared an individual wet mount of an Elodea leaf by placing a leaf from a micro-centrifuge tube onto a microscope slide, bearing its respective molarity, with the upper surface of the leaf face up. I placed a cover slip over the leaf and gently tapped the cover slip so as to seat it onto the slide and to remove any excess solution. I then viewed the wet mount-searching for indications of plasmolysis-under a microscope using the same 20X and 40X objective lenses and the 10X ocular lens I had viewed the dry mount and recorded my observations then repeated this process for each of the leaves in the remaining tubes. I was unable to obtain photos of my observations but I have included photos downloaded from the internet which were similar to what I had observed and provided them in tables 1-6 of section III(B). Having established which molarity of sucrose solution was isotonic with the cytosol of the cell (see table in section III(A)) I calculated the quantities of sucrose, glycerol (test solution) and 1-Propanol (counter test solution) I would need for the second part of this study. In those calculations I used the data presented in table 1 below. My calculations are presented in the Table of Calculations, table 3 of section III(C) infra. I plugged the results I obtained from table 3 into the formula C1 x V1 = C2 x V2 so that I may calculate the volumetric quantity of each of these chemicals I would need to add to each of my two 1 x 103 ÃŽà ¼L test solutions, my calculations for each may be found in Table 4 of section III(C). Using those calculation I then added the quantities of sucrose to each of the other two chemicals and subtracted the sum from the final volume of solution (1000 ÃŽà ¼L) I would be creating so that I will know the volume of deionized water (dH2O) I would need. Those calculations are shown in table 5 of section III(C). Using these calculations I then prepared 5 new micro-centrifuge tubes as follows: 3 tubes each containing a 1000 ÃŽà ¼L isotonic (0.4M) sucrose solution (one of which is to be used as a negative control); the fourth containing an aqueous solution of isotonic (0.4M) sucrose and 0.3M glycerol mixtures; and the fifth containing an aqueous solution of isotonic (0.4M) sucrose and 0.3M 1-Propanol mixtures (counter control). I placed one Elodea leaf into each of the 3 isotonic solutions and allowed them to soak for approximately five minutes. After five minutes I prepared a wet mount of the first of the 3 leaves as previously described. After viewing the first leaf (the negative control) I placed the second leaf on a slide and added 2 drops of the 0.3M glycerol/Sucrose solution to the slide then viewed and recorded my observations. I then prepared the third leaf using 2 drops of the 0.3M glycerol/Sucrose solution and viewed to be certain I obtained the same result as the last slide then after approximately 30 seconds added 2 drops of 1-Propanol/Sucrose solution (the counter test solution) to see if this would have an effect opposing that of the glycerol/Sucrose solution and recorded my observations which I describe next. Results A. Table of observations of Plasmolysis Table 2: Plasmolysis observations within five minutes of Elodeausing different sucrose solutions. Sucrose concentrations Plasmolysis observed (Y/N) Sucrose concentrations Plasmolysis observed (Y/N) B. Photograph tables (Photographs of Elodea leaves in various solutions): 1. Normal leaf (similar observation as prior to placing in solution) 2. Hypo-tonic solution (similar to observation as seen in 3. Isotonic solution (similar observation as in the isotonic solution and the ~0.4M-0.5M sucrose solutions) 4. Hyper-tonic solution (similar observation as seen in the 0.6M sucrose solution) 5. Plasmolysed leaf (similar observation as would have been seen in hyper-tonic solutions) 6. Plasmolysis Recovery (did not observe any recovery events but this is what I would also have been looking for had plasmolysis recovery taken place) C. Tables of Calculations: Table 3: Calculations for concentration of 0.3M glycerol/Sucrose solution. Amount of sucrose needed: [.137g] x V = 0.4M x .001 L V = (.0004g/L) / (0.137g) = 0.002919 L or 2.91 x 103mL Amount of glycerol needed: [0.028g] x V = 0.3M x .001 L V = (.0003g/L) / (0.028g) = 0.01071 L or 10.7 x 103mL Amount of 1-Propanol needed: [0.018g] x V = 0.3M x .001 L V = (.0003g/L) / (0.018g) = .01667 L or 16.7 x 103mL Table 4: Calculations of volumetric quantities of each chemical needed to make 1000 ÃŽà ¼L of each solution. 2.92 ÃŽà ¼L sucrose+ 10.7 ÃŽà ¼L glycerol + x(dH2O) = 1000 ÃŽà ¼L 13.62 ÃŽà ¼L + x(dH2O) = 1000 ÃŽà ¼L x(dH2O) = 1000 ÃŽà ¼L 13.62 ÃŽà ¼L x(dH2O) = 986.38 ÃŽà ¼L 2.92 ÃŽà ¼Lsucrose + 16.7 ÃŽà ¼L 1-Propanol + x(dH2O) = 1000 ÃŽà ¼L 19.62 ÃŽà ¼L + x(dH2O) = 1000 ÃŽà ¼L x(dH2O) = 1000 ÃŽà ¼L 19.62 ÃŽà ¼L x(dH2O) = 980.38 ÃŽà ¼L Table 5: Calculations of amounts to add to each solution. Discussion At first viewing I did not quite understand what was happening as I had not previously seen an Elodea leaf that presented without its large central vacuole let alone one that presented with chlorophyll throughout the entire cytosolic space. Having consulted with my fellow researchers (one of which obtained findings similar to mine in her experiment), none of whom had explanations for this result, I shall instead provide a summary of what I observed and what I had expected to observe. I had expected my first hypothesis to be borne out regarding the outward movement of water across the membrane and toward the hyper-tonic glycerol solution providing a sighting as in photograph 5, however what I discovered was an Elodea leaf showing absolutely no sign of plasmolysis. Instead of the expected I saw what was a leaf that appeared to be in a state of iso-osmolarity with its environment which would have been expected only in an isotonic solution as in photograph 3. There, also, was no turgor pressure as would have been seen in photograph 2 had the alternative hypothesis of inward movement of glycerol across the plasma membrane been borne out. Finally, had there been a plasmolysed cell the addition of the counter test solution of 1-propanol should have caused recovery as seen in photograph 6 but being I was unable to obtain a plasmolysed cell I was also unable to observe recovery of such cell. The results of this experiment has left me unable to either accept or reject either of the two hypotheses provided above.
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